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microglia    
小神经胶质; 格子细胞

小神经胶质; 格子细胞


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  • Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
    Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome Previously, Young and colleagues found that while SORL1-deficient hiPSC-derived neurons were choked with swollen endosomes, human microglial-like cells (hMGLs) had bulging lysosomes instead
  • New PET Tracers Visualize Activated and Homeostatic Microglia
    In trying to treat neuroinflammation, scientists need better ways to visualize microglia in the brains of living people Current microglial PET tracers target the mitochondrial transporter TSPO, but TSPO crops up in other cell types as well Several groups are working on new options In one such
  • After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods
    Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood For example, in cases of extensive plaque clearance, the cells upregulated myristoylated alanine-rich C kinase substrate, a protein involved in cell motility and phagocytosis, and fibroblast growth factor receptor 3 in addition to ApoE
  • Expunging Microglial Lipid Droplets Boosts Phagocytosis
    Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing fluorescently labeled inactivated E Coli or Aβ What if microglia were free of excessive lipids? To find out, researchers targeted FIT2, a protein embedded in the endoplasmic reticulum that helps lipid droplets form and bud
  • Lipid-Laden, Sluggish Microglia? Blame Aβ. | ALZFORUM
    Microglia and macrophages make lipid droplets when stressed by inflammation Scientists believe the lipids sustain the cells’ metabolic need, enabling them to respond to threats (van Dierendonck et al , 2022; reviewed by Olzmann and Carvalho, 2019) Wyss-Coray previously described lipid-droplet accumulating microglia (LDAMs) that spewed pro-inflammatory cytokines in the hippocampi of old
  • ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
    Mouse microglia got a genetic tune-up On 9 June in Nature Aging, researchers led by Warren G Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing human angiotensin-converting enzyme (ACE) in mouse microglia boosts their uptake of Aβ, clearing out plaques in a model
  • Releasing the Brakes on SYK Kinase Fires Up Microglia
    PTP1B knockout microglia made more ATP than did PTP1B+ cells, and they better amped up glycolysis after being stimulated with Aβ oligomers Conversely, treating PTP1B knockout microglia with a SYK inhibitor depressed their metabolism and phagocytic abilities to the level of PTP1B+ cells, establishing SYK as the key mechanism
  • C5aR1+ microglia exacerbate neuroinflammation and cerebral edema in . . .
    Together, these findings establish C5aR1-positive microglia as a central driver of neuroinflammation-induced cerebral edema and highlight microglial C5aR1 as a promising therapeutic target for acute brain injury
  • Lymphoid gene expression supports neuroprotective microglia function . . .
    An open question is whether CD28 + PU 1 low microglia are related to T cell interaction, recruitment and or activation, but collectively, both studies endorse the relevance of investigating the plasticity of plaque-associated microglia, and they suggest that known adaptive-immune checkpoints control a neuroprotective microglial state





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