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  • Pemetrexed induces ROS generation and cellular senescence by . . .
    Our findings illuminate the potential mechanism of TS‐triggered gefitinib resistance and indicate inhibition of TS by pemetrexed can potentiate the effect of gefitinib in NSCLC Pemetrexed combined with gefitinib has potent anti‐progression potential in gefitinib‐resistant NSCLC
  • Pemetrexed induces apoptosis in malignant mesothelioma and . . .
    Pemetrexed enhanced caspase-dependent apoptosis, induced intracellular ROS generation, and downregulated SIRT1 in the MSTO-211 and A549 cells Pemetrexed-induced apoptosis, which was prevented by pretreatment with N-acetyl-cysteine (NAC), was mediated by effects on the mitochondria, including mitochondrial membrane potential transition (MPT
  • Pemetrexed - StatPearls - NCBI Bookshelf
    Adverse effects associated with pemetrexed are primarily caused by dose-related toxicities One of the most frequent adverse events is myelosuppression Patients have a higher risk of myelosuppression if they are not administered vitamin supplementation before, during, and after undergoing pemetrexed therapy
  • P28-7 Effects of pemetrexed disodium heptahydrate on . . .
    Results showed that pemetrexed induced the apoptosis of PC9 cells, which was accompanied by an increase in ROS and a decrease in MMP Pemetrexed inhibited Bcl-2 expression, whereas Bax expression was enhanced, and cytochrome c was released
  • Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non . . .
    Emerging evidence indicates that combining pemetrexed with histone deacetylase inhibitors (HDACi) may enhance therapeutic efficacy in non-small cell lung cancer (NSCLC)
  • Molecular mechanism implicated in Pemetrexed-induced . . .
    We found that MTA induces caspase-dependent and -independent apoptosis in human melanoma cells through intracellular ROS accumulation, which in turn promotes DNA damage and consequent p53-regulated gene expression changes





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