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  • People With Severe Diabetes Are Cured in Small Trial of New . . .
    A person’s conventional supplies for treating type 1 diabetes A single infusion of a new treatment, called zimislecel, may have cured 10 out of 12 people with the most severe form of the disease
  • Zimislecel, a novel cell therapy, appears to restore islet . . .
    Results from the phase 1 2 portion of the FORWARD-101 trial, which enrolled patients with type 1 diabetes with severe hypoglycemic events and impaired hypoglycemic awareness, were presented at the
  • Phase 3 Trial of Vertex’s Islet Cell Therapy for Type 1 . . .
    Zimislecel is an allogeneic stem cell-derived islet cell therapy that could eliminate the need for insulin in those who have type 1 diabetes Regulatory submissions are expected in 2026, and if approved, would be the second cell therapy for type 1 diabetes
  • Son’s diabetes diagnosis sent scientist on quest for cure
    In 2019, the company was acquired by Vertex, and it now conducts clinical trials for people with Type 1 Melton said more than a dozen patients have completed the trial and “more than a handful” who have taken this new treatment are “insulin independent” — meaning they have not required additional exogenous insulin thus far
  • Stem Cell Breakthrough Offers Hope for Type 1 Diabetes Cure
    In a groundbreaking evolution of diabetes therapy, scientists have made a major leap toward a sustainable, potentially curative treatment for type 1 diabetes For decades, the primary strategy for treating this autoimmune disease has revolved around the administration of exogenous insulin
  • Expanded FORWARD Trial Demonstrates Continued Potential for . . .
    Participants who received a full dose of VX-880 as a single infusion demonstrated engraftment of islet cells and endogenous insulin (C-peptide) production, eliminated severe hypoglycemic events, and significantly improved glycemic control while simultaneously reducing or eliminating insulin use
  • World First: Stem Cells Reverse Type 1 Diabetes in Clinical Trial
    Now, the successful treatment of the condition in a young woman in China has brought the possibility of a universal cure tantalizingly close In June 2023, doctors injected the equivalent of roughly 1 5 million insulin-producing cells into the patient's abdominal muscles





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