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  • Rechallenge therapy versus tyrosine kinase inhibitor (TKI . . .
    Abstract Currently, the standard third-line treatment options for advanced metastatic colorectal cancer (mCRC) include regorafenib, fruquintinib, and trifluridine tipiracil (TAS-102), but these drugs have limited clinical efficacy This study aims to evaluate the efficacy and survival outcomes of tyrosine kinase inhibitor (TKI) versus chemotherapy rechallenge in third-line treatment for
  • Lost in translation: Revisiting the use of tyrosine kinase . . .
    Patients with advanced or metastatic colorectal cancer ( (m)CRC) have limited effective treatment options resulting in high mortality rates A better understanding of the molecular basis of this disease has led to growing interest in small molecule tyrosine kinase inhibitors (TKIs) for its treatment
  • Zanzalintinib Atezolizumab Improves CRC Survival, Expands TKI . . .
    New trial results reveal zanzalintinib and atezolizumab significantly enhance survival in metastatic colorectal cancer, marking a breakthrough in treatment options
  • RETRACTED ARTICLE: Rechallenge therapy versus tyrosine kinase . . .
    Colorectal cancer (CRC) is the third most common cause of cancer and the second most common cause of cancer-related death worldwide At least 50% of patients will experience metastasis, with the
  • Multi-omics characterization of response to tyrosine kinase . . .
    Multi-omics characterization of response to tyrosine kinase inhibitor plus immunotherapy in MSS pMMR metastatic colorectal cancer: A multicenter biomarker study If you have the appropriate software installed, you can download article citation data to the citation manager of your choice
  • Treatment Combinations Based in Immune Checkpoint Inhibitors . . .
    Patients with heavily pretreated microsatellite stable metastatic colorectal cancer (CRC) had survival benefits after using combinations based in immune checkpoint inhibitors
  • Updates in the Treatment of Metastatic Colorectal Cancer
    Molecular biomarker testing for all patients with metastatic colorectal cancer (CRC) has become increasingly important because identifying targetable alterations can lead to meaningful clinical benefits At a minimum, testing should include RAS, BRAF mutational status, microsatellite instability status, HER2 expression, NTRK, and RET mutations For HER2-amplified cancer, the NCCN Guidelines
  • 96P Tyrosine kinase inhibitor (TKI) plus PD-1 blockade in TKI . . .
    96P Tyrosine kinase inhibitor (TKI) plus PD-1 blockade in TKI-responsive MSS pMMR metastatic colorectal adenocarcinoma (mCRC): Updated results of TRAP study J Zhang 1 ∙ Q Dong
  • Abstract 6002: Tyrosine kinase inhibitor (TKI) plus PD-1 . . .
    Tyrosine kinase inhibitor (TKI) plus PD-1 blockade in TKI-responsive MSS pMMR metastatic colorectal adenocarcinoma (mCRC): Results of a multicenter, phase II trial (TRAP) [abstract] In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL
  • Anlotinib Combined With Sintilimab as First-line Treatment . . .
    Diagnosis of any malignancy other than advanced colorectal cancer within the 5 years preceding the start of study treatment, except for carcinoma in situ of the cervix, cured basal cell carcinoma, or bladder epithelial tumors





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