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  • Desmopressin to reduce periprocedural bleeding and . . .
    A small RCT of 100 patients who underwent coronary artery bypass surgery found that the coadministration of desmopressin and TXA reduced transfusion requirements when compared to the combination of desmopressin and protamine,(Ozal et al 2002) but the potential synergy between desmopressin and TXA could not be evaluated in the absence of groups
  • Desmopressin to reduce periprocedural bleeding and . . .
    We systematically reviewed the literature to investigate the effects of peri-procedural desmopressin in patients without known inherited bleeding disorders undergoing surgery or other invasive procedures We included 63 randomized trials (4163 participants) published up to February 1, 2023 Seven trials were published after a 2017 Cochrane systematic review on this topic There were 38 trials
  • What is the utility in using desmopressin for post-operative . . .
    There is conflicting evidence available on the use of desmopressin for the management of post-operative bleeding While some studies report overall significant reduction of blood loss and transfusion requirements in patients who receive desmopressin for postoperative bleeding management, others have found little to no difference in bleeding reduction and transfusions Despite the lack of
  • Effect of Desmopressin on Bleeding After Heart Surgeries: A . . .
    diatric heart surgery During the past years, researchers have found that desmopressin does not significantly affect the hemostatic status of children undergoing surgery, and this drug does not play a role in reducing bleeding after heart surgery in children (14) During the study of children undertwoyearsof ageundergoingheartsurgery, Reynolds
  • Effect of Desmopressin on Bleeding After Heart Surgeries: A . . .
    Therefore, prophylactic desmopressin does not effectively reduce bleeding after surgery and is only slightly effective in controlling bleeding in patients with extensive bleeding According to other studies on the role of desmopressin in coronary, valvular, and fusion surgery, the drug did not reduce the need to receive blood products ( 23 , 33 )
  • Efficacy and Safety of Desmopressin in Terms of Bleeding and . . .
    Medical management of bleeding during cardiac surgery is not well established Diagnosis and treatment depend mainly on the clinician’s choice and institutional algorithms Although many haemostatic agents are currently available, the indications for desmopressin remain unclear


















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