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  • Trazodone-Induced Priapism and Increased Recurrence Risk With . . .
    Venous occlusion causes decreased cavernous arterial inflow, which leads to tissue hypoxia and, if untreated, irreparable damage to penile tissue (1, 2) Other forms include arterial (high-flow nonischemic) and stuttering (recurrent or intermittent) priapism
  • Pathophysiology of prolonged penile erection associated with . . .
    We conclude that trazodone can enhance penile erection in man and propose a mechanism related to the alpha-adrenoceptor blocking properties of trazodone by interference with the sympathetic control of penile detumescence
  • Trazodone Priapism: Risks, Symptoms, Management
    These factors suggest an underlying predisposition to impaired blood flow dynamics in the penis Furthermore, concomitant substance use can also play a significant role Alcohol, for example, can potentiate the vasodilatory effects of trazodone, further reducing the capacity for venous outflow
  • What is the cause of priapism associated with trazodone . . .
    Trazodone can cause priapism through its alpha-adrenergic blocking effects, particularly at the alpha-1 receptors in penile tissue, leading to a prolonged, painful erection that persists without sexual stimulation
  • Pretreatment screening and counseling on prolonged erections . . .
    With all the studies performed to understand the mechanism of action of trazodone and other antipsychotics, the most widely accepted mechanism involves a decrease in local sympathetic tone with respect to the local parasympathetic tone
  • Priapism and Trazodone: Exploring the Link - WowRxPharmacy
    Norepinephrine modulation: Trazodone impacts Norepinephrine reuptake, affecting the sympathetic nervous system, which regulates processes like blood vessel constriction An imbalance in this system may lead to abnormal blood flow in the penis, possibly causing Priapism; Serotonin modulation: Trazodone affects Serotonin levels, which regulate
  • Trazodone Priapism: Earning the Nickname TrazoBONE
    How does trazodone cause priapism? (Mechanisms) Trazodone-induced priapism is almost always associated with low flow (ischemic) pathology and is currently hypothesized to be caused by alpha-1 adrenergic receptor antagonism





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