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  • CHIP as a therapeutic target for neurological diseases
    These results indicate that small-molecule agonists of CHIP such as sulforaphane may constitute promising drugs that could be used for the treatment of neurological diseases
  • CHIP STUB1 Ubiquitin Ligase Functions as a Negative Regulator . . . - PubMed
    Our findings reveal new insights into mechanisms that control the surface expression of overexpressed ErbB2 and suggest that reduced CHIP expression may specify ErbB2-overexpressing breast cancers suitable for combined treatment with Trastuzumab and ER stress inducing agents
  • STUB1 CHIP: New insights in cancer and immunity
    STUB1 regulates inflammatory response, autoimmunity, anti-viral and anti-tumor immune responses STUB1 represents a promising and valuable therapeutic target in cancer and immunology
  • Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is . . .
    Using adoptive transfer of anergic B cells with subsequent acute induction of gene deletion or expression, we demonstrate that the continuous activities of independent inhibitory signaling pathways involving the tyrosine phosphatase SHP-1 and the inositol phosphatase SHIP-1 are required to maintain anergy
  • CHIP蛋白在疾病中的作用研究进展 - bnujournal. com
    CHIP (carboxyl terminus of Hsc70-interacting protein)又称STUB1 (STIP1 homology and U-box containing protein 1)，是一种分子伴侣结合蛋白，具有E3泛素连接酶活性．研究表明，CHIP蛋白在细胞体内通过蛋白质量控制系统调控细胞代谢、分化、增殖、迁移和肿瘤发生发展等多种生理病理过程．本文对CHIP在癌症及多种常见疾病中的作用进行综述，以期为临床治疗和药物开发提供潜在突破点．
  • Alpha-1 Receptor Agonists - StatPearls - NCBI Bookshelf
    Alpha-1 agonists are a class of medications used in the management of many disorders, including vasodilatory shock, hypotension, hypoperfusion, septic shock, cardiopulmonary arrest, heart failure decompensation, as well as other lower acuity conditions
  • STUB1 CHIP: New insights in cancer and immunity - PubMed
    The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13 3, encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase involved in protein quality control
  • Emerging Neuroprotective Potential of GLP-1 Receptor Agonists
    GLP-1 receptor agonists (GLP-1RAs) exemplify MTMC agents, with pleiotropic anti-inflammatory effects that span pathways such as NF-κB and Toll-like receptors
  • Glucagon‐like peptide‐1 receptor agonists to expand the healthy . . .
    Glucagon‐like peptide 1 receptor agonists (GLP‐1 RAs) have proven beneficial in type 2 diabetes, are amongst the few medicines approved for weight management, and are also licensed for focused cardiovascular risk reduction





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