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  • MYC as a target for cancer treatment - PubMed
    Because of its high prevalence of deregulation and its causal role in cancer formation, maintenance and progression, targeting MYC is theoretically an attractive strategy for treating cancer
  • MYC as a target for cancer treatment
    Because of its high prevalence of deregulation and its causal role in cancer formation, maintenance and progression, targeting MYC is theoretically an attractive strategy for treating cancer
  • MYC in cancer: from undruggable target to clinical trials
    MYC is among the most infamous oncogenes in cancer A notable feature that distinguishes it from other common oncogenes is that its deregulation is not usually due to direct mutation, but
  • Targeting oncogenic Myc as a strategy for cancer treatment
    In this review, we summarize the latest advances in targeting oncogenic Myc, particularly for cancer therapeutic purposes Cancer: Therapeutic strategies target myc from all directions The cancer gene myc is the subject of a variety of research strategies aimed at developing anti-cancer therapies
  • Targeting MYC’s Achilles heel yields new potential cancer . . . - AAAS
    “Disabling MKLP2 with JMBI-001 exacerbates these MYC-enabled vulnerabilities, selectively killing cancer cells while sparing normal cells ” We have developed JMBI-001 as a versatile monotherapy with broad and potent tumor-suppressive activity against MYC-driven cancers
  • Massey researchers discover new genetic target that could shape the . . .
    Hepatocellular carcinoma (HCC), the most common type of liver cancer and the third-leading cause of cancer-related deaths worldwide, is extremely challenging to treat However, the future of HCC patient care looks brighter thanks to research by Devanand Sarkar, M B B S , Ph D , who discovered that the gene TAF2 plays a pivotal role in the
  • Alternative approaches to target Myc for cancer treatment
    In this review, after a comprehensive summarization of valuable sources for potential druggable targets of Myc-driven cancer, we also peer into the promising future of utilizing macropinocytosis
  • MYC TET3‐Regulated TMEM65 Activates OXPHOS‐SERPINB3 Pathway to Promote . . .
    MYC is one of the most frequently altered driver genes in TNBC, which is amplified in about 40% of TNBC and drives multiple oncogenic gene expression programs to promote disease progression and therapeutic resistance (Fudan University Shanghai Cancer Center) without any treatment All procedures were approved by the Medical Ethics
  • MYC as a target for cancer treatment - ScienceDirect
    Because of its high prevalence of deregulation and its causal role in cancer formation, maintenance and progression, targeting MYC is theoretically an attractive strategy for treating cancer
  • MYC and therapy resistance in cancer: risks and opportunities
    Therapy resistance is a major limitation in clinical oncology The MYC oncogene not only drives cancer progression, but also favors resistance to classical chemotherapy and targeted therapies





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