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  • Clinical efficacy and mechanisms of biologics for chronic . . .
    outcomes of biologic therapy versus endoscopic sinus surgery, and discuss therapies in development and future directions (J Allergy Clin Immunol 2025;155:1401-10 ) Key words: Chronic rhinosinusitis, nasal polyp, CRSwNP, CRSsNP, biologic, benralizumab, dupilumab, mepolizumab, omalizumab, tezepelumab Chronic rhinosinusitis (CRS) encompasses a
  • Chinese Position Paper on Biologic Therapy for Chronic . . .
    Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP) Despite the limited availability of registered biologics for CRSwNP treatment in China, the count …
  • AAAAI 2025: Twice-yearly novel biologic shows promise in . . .
    AAAAI 2025: Twice-yearly novel biologic shows promise in chronic rhinosinusitis with nasal polyps March 5, 2025 Depemokimab, an anti-IL-5 biologic administered biannually, offers a promising new treatment option for patients with chronic rhinosinusitis with nasal polyps (CRSwNP), significantly reducing polyp size and nasal congestion while maintaining a favorable safety profile
  • Ultra-long-acting biological therapy for chronic . . . - The Lancet
    Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a common and particularly severe subset of sinonasal inflammatory disease that is characterised by benign outgrowths of the inflamed mucosa The management framework of CRSwNP substantially shifted with the introduction of biological agents 1–3 These therapies, targeting the Th2 cell cytokine pathways, drove reductions in both systemic
  • Clinical efficacy and mechanisms of biologics for chronic . . .
    Tissue IgE levels positively correlate with the regrowth of nasal polyps, and sensitization to environmental aeroallergens can predict the need for repeat ESS 96 Treatment of CRSwNP with an anti-IgE biologic (omalizumab) resulted in a significant reduction in nasal polyp size as well as in symptom severity scores for patients both with and





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