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  • 带你全面了解靶点NRP1 - 知乎
    NRP1 (神经纤毛蛋白）是一种单次跨膜、非酪氨酸激酶表面糖蛋白，在所有脊椎动物中都存在，在物种间高度保守。 已知存在两种同源的NRP亚型，即NRP1和 NRP2，由不同的基因编码，这两种NRP最初被发现为神经元粘附分子。 后来发现它们与血管生物学有关，正常胚胎血管发育需要NRP1和NRP2参与小淋巴管和毛细血管的形成。 过去10年的研究表明，NRP是一种多功能蛋白质，参与除神经和血管发育以外的多种生物过程，其中NRP1起在免疫和肿瘤发生中起主要作用。 NRP-1主要在激活的T 细胞 和 B细胞 中表达，功能是 抑制细胞 的激活，这是 免疫系统 的一种正常的自稳机制，因为过度的T B细胞激活会引起 自身免疫病，所NRP1是我们人体的一道 护身符。
  • NRP1 Gene - GeneCards | NRP1 Protein | NRP1 Antibody
    NRP1 (Neuropilin 1) is a Protein Coding gene Diseases associated with NRP1 include Covid-19 and Age Related Macular Degeneration Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Semaphorin interactions
  • Novel small peptides derived from VEGF - Nature
    In this study, we identified two peptides (QKRKRKKSRKKH and RKRKRKKSRYIVLS) derived from VEGF 125-136 that displayed high binding affinities to VEGFR and strong inhibition of A549 cell growth 99m
  • NRP1 cripples immunological memory - Nature Immunology
    NRP1 is a type I transmembrane protein that can bind several ligands, including semaphorins 3a and 4a, vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β),
  • NRP1 interacts with endoglin and VEGFR2 to modulate VEGF . . . - Nature
    Endothelial cells express neuropilin 1 (NRP1), endoglin (ENG) and vascular endothelial growth factor receptor 2 (VEGFR2), which regulate VEGF-A-mediated vascular development and angiogenesis
  • NRP1 is a receptor for mammalian orthoreovirus engaged by distinct . . .
    In this study, we identified murine neuropilin 1 (mNRP1) as a receptor for reovirus mNRP1 binds reovirus with nanomolar affinity using a unique mechanism of virus-receptor interaction, which is coordinated by multiple interactions between distinct reovirus capsid subunits and multiple NRP1 extracellular domains
  • Neuropilin-1 is a T cell memory checkpoint limiting long-term . . . - Nature
    Here we report that mice with a CD8 + T cell–restricted neuropilin-1 (NRP1) deletion exhibited substantially enhanced protection from tumor rechallenge and sensitivity to anti-PD1
  • Neuropilin 1: function and therapeutic potential in cancer
    As a therapeutic target, NRP1 allows simultaneous targeting of NRP1-expressing tumour vasculature, NRP1+ Tregs and pDCs With the development of anti-NRP1 monoclonal antibodies and cell-penetrating peptides, NRP1 represents a promising new target for cancer therapies
  • Neuropilin-1 mediates lung tissue-specific control of ILC2 . . . - Nature
    Here, we show neuropilin-1 (Nrp1), which is induced postnatally and sustained by lung-derived transforming growth factor beta-1 (TGFβ1), is a tissue-specific marker of lung ILC2s
  • Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA . . .
    We identify a splice variant of tryptophanyl-tRNA synthetase (mini-WARS) as an unconventionally secreted extracellular inhibitory ligand of NRP1 that, by stabilizing it at the AJs, slows down





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