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  • Memantine is the best treatment I have ever tried for ADHD. If . . . - Reddit
    From wikipedia: "Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors By binding to the NMDA receptor with a higher affinity than Mg2+ ions, memantine is able to inhibit the prolonged influx of Ca2+ ions, particularly from extrasynaptic receptors, which forms the basis of neuronal excitotoxicity
  • Memantine: A beginners recreational guide : r Drugs - Reddit
    Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses It's clean feeling, compared to DXM
  • One Month of Memantine : r Nootropics - Reddit
    Main reasons I started memantine again were for the anti-anhedonia effects and for general focus motivation and wellbeing Prior to starting memantine I was struggling with motivation and energy, and have for years Have trialed the substance before for approx 1 month First 2 weeks were incredible
  • Memantine : r Nootropics - Reddit
    Memantine is great It is a long acting NMDA receptor antagonist that binds to an open channel binding site This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block Then memantine is pulled into the channel to its binding site
  • Memantine : r Nootropics - Reddit
    Memantine is obviously one of the safer NMDA antagonists, but it has still been noted to cause vacuolation and neuronal damage at high doses in rodents The toxic dose in humans is not known, but extrapolating from the therapeutic-to-toxic ratio in rodents, you are definitely flirting with this toxicity
  • Why is memantine stopping amphetamine or methylphenidate from . . . - Reddit
    Too much of either blunts voltage-gated calcium channels (NMDA) and forcing a higher required voltage (more stimulation) to elicit action potentials Memantine is shown to displace magnesium and block channels with higher affinity, thus also forcing magnesium to bind to what it can, which can further block excitability
  • Memantine: The Unknown Dissociative - Reddit
    “Memantine was started at 5 or 10 mg QHS, before being increased by 5 or 10mg every 4-7 days, as tolerated, to a maximum dose of 40 mg - 60 mg, as tolerated In all, 13 patients showed complete remission from CRPS with VAS 0 and the disappearance of allodynea for at least nine months after the use of memantine
  • Warning reminder on Memantine use. : r Nootropics - Reddit
    "The main finding of this study therefore, is that mice trained-on memantine to one platform location are later impaired in spatial learning when trained-off memantine, introducing the possibility that spatial learning for platform locations acquired when training-on memantine inhibited learning in subsequent trainingoff the drug
  • Memantine as a neuroprotective, memory enhancing agent, and . . . - Reddit
    I have experience with memantine at various doses, and I'll admit the positive cognitive benefits vary greatly between individuals and finding the proper dosage is key The biggest hurdle is the one to two week adjustment period when starting, which presents a number of negative side effects
  • [UPDATE] Memantine for ADHD : r Nootropics - Reddit
    Honestly, I think it's because Memantine + nicotine is a bad combo, especially for those (like me) who are addicted to the habituating effects of cigarettes Memantine is a nAchr antagonist, which feels unpleasant, if you smoke regularly This is only my theory





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