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  • Entry - *156540 - METHYLTHIOADENOSINE PHOSPHORYLASE; MTAP - OMIM . . .
    MTAP-deleted cells accumulate the metabolite methylthioadenosine (MTA), which the authors found inhibited PRMT5 methyltransferase activity Deletion of MTAP in MTAP-proficient cells rendered them sensitive to PRMT5 depletion Conversely, reconstitution of MTAP in an MTAP-deficient cell line rescued PRMT5 dependence
  • Home - OMIM - (OMIM. ORG)
    Online Mendelian Inheritance in Man (OMIM) is a comprehensive, authoritative compendium of human genes and genetic phenotypes that is freely available and updated daily The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 15,000 genes
  • MTAP Gene - GeneCards | MTAP Protein | MTAP Antibody
    MTAP (Methylthioadenosine Phosphorylase) is a Protein Coding gene Diseases associated with MTAP include Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma and Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome Among its related pathways are Interleukin-12 family signaling and Methionine de novo and salvage pathway
  • MTAP - Wikipedia
    MTAP is a phosphorylase, which is an enzyme that catalyzes the addition of an inorganic phosphate to another molecule MTAP is responsible for the cleaving of its substrate, MTA, into adenine and 5-methylthioribose-1-phosphate by the addition of the inorganic phosphate to the 1-prime carbon of the ribose sugar unit MTA [20]
  • Orphanet: MTAP-methylthioadenosine phosphorylase
    lovd: mtap Diseases List Disease-causing germline mutation(s) in Diaphyseal medullary stenosis-bone malignancy syndrome ORPHA:85182
  • OMIM数据库使用指南 - 知乎 - 知乎专栏
    OMIM(Online Mendelian Inheritance in Man)数据库,中文称在线人类孟德尔遗传数据库。 OMIM侧重于疾病表型与其致病基因之间的关联。 OMIM网址 http: www omim org
  • Home - OMIM - NCBI
    OMIM is a comprehensive, authoritative compendium of human genes and genetic phenotypes that is freely available and updated daily OMIM is authored and edited at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, under the direction of Dr Ada Hamosh
  • MTAP | Cancer Genetics Web
    The MTAP substrate methylthioadenosine (MTA) accumulates upon MTAP loss Biochemical profiling of a methyltransferase enzyme panel revealed that MTA is a potent and selective inhibitor of PRMT5 MTAP-deleted cells have reduced PRMT5 methylation activity and increased sensitivity to PRMT5 depletion
  • OMIM获取疾病基因(二) - 知乎专栏
    OMIM(Online Mendelian Inheritance in Man),即在线《人类孟德尔遗传》数据库。 访问网址如下: https: www omim org 进入OMIM主页之后点击“Gene Map”,如图2 以“胰腺癌”为例,搜索框输入“pancreatic cance…
  • MTAP methylthioadenosine phosphorylase [ Homo sapiens (human) ]
    Title: MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways BAP1 and Claudin-4, But Not MTAP, Reliably Distinguish Borderline and Low-grade Serous Ovarian Tumors From Peritoneal Mesothelioma





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